One thing everyone should know

  • Print
AddThis Social Bookmark Button

Pretesting for DPD Deficiency is recommended before treatment with any 5-FU based drug

DPD Deficient patients who are prescribed 5-FU based medications experience serious illness with potentially a 30% mortality rate.

  When a DPD deficient person is treated with 5-FU, the drug’s normal life span in the body is increased greatly.  Instead of being metabolized and being expelled, it remains in the body where it is toxic to normal cells.  Depending on the level of DPD deficiency and the amount of 5-FU administered, it will lead to great suffering, long term disabilities and even death. 

 According to the NIH, 1,300 are killed annually by 5-fu toxicity

5-FU (Fluorouracil) is a potent chemotharapy drug used to treat Colon Cancer, Gastrointestinal Cancers,Esophageal; Pancreatic, Gastric, Inflammatory Breast Cancer, Ovarian and other forms of cancer. (as a key component of Tegafur-uracil). It may also be prescribed for skin conditions such as Actinic Keratoses.
Unfortunately for those who are unaware that they are DPD deficient these drugs are potentially life threatening.   These drugs are often times prescribed using the tradenames listed below:

Fluorouracil, 5-Fu, Adrucil, Carac, Efudex , Fluoroplex, Xeloda , Capecitabine

*Uracil based medications which reference DPD Deficiency and/or 5-fu toxicity.

Names used outside U.S.

AccuSite, Actino-Hermal, Arumel, Efurix, Fiverocil, Flurablastin, Fluracedyl, Fluracil, Fluril, Fluroblastin, Flurox, Ribofluor, Timazin